Health Issues » thyroxine http://healthwriter.eu tried to be explained Wed, 07 Jul 2010 16:07:14 +0000 en hourly 1 http://wordpress.org/?v=3.0 Thyroxine Effects and Hypothyroidism http://healthwriter.eu/thyroxine-effects-and-hypothyroidism/ http://healthwriter.eu/thyroxine-effects-and-hypothyroidism/#comments Wed, 08 Apr 2009 09:35:38 +0000 Jan Modric http://healthwriter.eu/?p=62 Thyroxine Effects
  • Increases Basal Metabolic Rate (BMR) > increased heat production 

Hypothyroidism

What Lowers TSH Release (1)

Pituitary (hypophysis) hormone TSH (thyroid stimulating hormone) stimulates thyroid to release thyroxine (T4) and triiodothyronine (T3). T4 and T3, when they reach a certain level, lower release of TSH by negative feedback loop. In low T4/T3 (hypothyroidism) TSH will be high, and in high T4/3 (hyperthyroidism) TSH will be low (1). Other factors that lower TSH level:

  • Long term stress
  • Prolonged cortisol excess
  • Aging
  • Infection
  • Fever
  • Trauma
  • Caffeine
  • Somatostatin
  • Dopamine or L-dopa
  • Adrenaline (sometimes)
  • Amphetamine

Above factors may cause that TSH will be normal, despite hypothyroidism (2).

Symptoms of Hypothyroidism (3):

  • Fatigue
  • Insomnia
  • Depression
  • Anxiety and panic attacks
  • Decreased memory
  • Inability to concentrate
  • Weight gain
  • Fluid retention
  • Puffy face, swollen eyelids
  • Dull facial expression
  • Swollen legs and feet, swollen hands, swollen abdomen
  • Carpal tunnel syndrome
  • Constipation
  • Headaches
  • Brittle nails
  • Dry skin
  • Elbow keratoses
  • Yellowish discoloration of the skin
  • White patches on the skin (vitiligo)
  • Diffuse hair loss
  • Coarse dry hair
  • Menstrual irregularities
  • Poor circulation
  • Muscle and joint pain
  • Morning stiffness
  • Muscle cramps
  • Reduced heart rate
  • Low blood pressure
  • Slow movements
  • Decreased sexual interest
  • Low body temperature
  • Cold intolerance, cold hands and feet
  • Husky voice
  • Increased LDL

Thyroid Function and Cortisol

Cortisol controls thyroxine activation at the cell level. Often, symptoms of hypothyroidism are due to adrenal hormone imbalances. If a trial of thyroid hormone resulted in significant but temporary relief of symptoms of hypothyroidism, blood cortisol levels and rhythm should be checked (4).

References:

  1. Thyroid function  (endocrineweb.com)
  2. What lowers TSH release  (doctorsaredangerous.com)
  3. Hypothyroidism symptoms  (worldhealth.net)
  4. Cortisol influence on thyroxine activity  (nutrition4health.org)
]]> http://healthwriter.eu/thyroxine-effects-and-hypothyroidism/feed/ 2